Advances in the targeting of HIF-1α and future therapeutic strategies for glioblastoma multiforme (Review).

@article{Wang2017AdvancesIT,
  title={Advances in the targeting of HIF-1α and future therapeutic strategies for glioblastoma multiforme (Review).},
  author={Gang Wang and Jun-jie Wang and Xing-li Fu and Rui Guang and Shing-shun Tony To},
  journal={Oncology reports},
  year={2017},
  volume={37 2},
  pages={
          657-670
        }
}
Cell metabolism can be reprogrammed by tissue hypoxia leading to cell transformation and glioblastoma multiforme (GBM) progression. In response to hypoxia, GBM cells are able to express a transcription factor called hypoxia inducible factor-1 (HIF-1). HIF-1 belongs to a family of heterodimeric proteins that includes HIF-1α and HIF-1β subunits. HIF-1α has been reported to play a pivotal role in GBM development and progression. In the present review, we discuss the role of HIF-1α in glucose… CONTINUE READING

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