Advances in the science of estrogen receptor modulation.

@article{Meegan2003AdvancesIT,
  title={Advances in the science of estrogen receptor modulation.},
  author={Mary J. Meegan and David G. Lloyd},
  journal={Current medicinal chemistry},
  year={2003},
  volume={10 3},
  pages={
          181-210
        }
}
This work details recent advances in the science of estrogen receptor (ER) modulation, with emphasis on the discovery of novel ligands for the ER ligand binding domain (LBD). A detailed examination of structural studies of the ERs is presented with analysis of the impact of such works on contemporary ligand design and the molecular pharmacology of the ER. The various classes of ER modulators are discussed on the basis of stuctural similarities including selective estrogen receptor modulators… CONTINUE READING

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