Advances in the pathophysiology of tension-type headache: From stress to central sensitization

@article{Chen2009AdvancesIT,
  title={Advances in the pathophysiology of tension-type headache: From stress to central sensitization},
  author={Yaniv Chen},
  journal={Current Pain and Headache Reports},
  year={2009},
  volume={13},
  pages={484-494}
}
  • Yaniv Chen
  • Published 9 December 2009
  • Psychology
  • Current Pain and Headache Reports
Tension-type headache (TTH) is the most common and most socioeconomically costly headache. Yet our knowledge regarding TTH pathophysiological mechanisms is still in its early stages. Psychological stress and weak coping mechanisms may initiate and propagate physiological pain via activation of second messengers in downstream substrates involved in pain. It seems that peripheral mechanisms are predominant in the episodic type (ETTH), whereas central mechanisms are involved in the chronic type… 
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Immunology Aspects in Tension-Type Headache Chronicity
TLDR
A deeper understanding of the immune system's role in the pathophysiological process and modulation of chronic pain could be a potential target for developing therapies in managing chronic pain.
Primary headaches in patients with temporomandibular disorders: Diagnosis and treatment of central sensitization pain
TLDR
The importance of excluding chronic neuropathic pain and recognizing CS as the main component using a top-down approach to target the best pharmacological and non-pharmacological treatments is evident.
Cholinergic mechanisms of headaches
TLDR
The cholinergic neurotransmitter system in the pathophysiology of various forms of headaches is reviewed and the ACh-dependent mechanisms of the anticephalalgia action of pharmacological and nonpharmacological approaches used for the headache treatment are discussed.
The contribution of clinical neurophysiology to the comprehension of the tension-type headache mechanisms
Neurotrophic factors in tension-type headache Fatores neurotróficos na cefaleia do tipo tensional
TLDR
It is reasonable to hypothetize that NF may be involved in TTH pathogenesis, and may play a role in nociception by regulating peripheral sensitivity of nocICEptors and by modulating the central processing of nOCiceptive information.
Neurotrophic factors in tension-type headache.
TLDR
It is suggested that the serum levels of NF are not altered in TTH, and depression and anxiety scores as well as headache impact did not correlate with NF levels.
Neuromodulation and Other Non-pharmacological Approaches in Tension-Type Headache
TLDR
In the pathophysiology of tension headache, both central and peripheral mechanisms are involved, which can potentially be modified by non-pharmacological and neuromodulation techniques.
Epidemiology of Tension-type Headache
TLDR
This review will focus on the epidemiologies of episodic and chronic TTH in various age groups, factors associated with progression and remission, comorbidities, and the burden of TTH.
Osteopathic Manipulative Treatment in Tension Headaches
TLDR
A case of tension headache initially non-responsive to pain medication but resolved with osteopathic manipulative treatment and lifestyle modifications is presented.
An unusual cause of symptomatic tension-type headache: Hypertrophic branchial myopathy
TLDR
Future studies are needed to define parameters and estimate the prevalence of this entity among those with tension-type headache, and hypertrophic branchial myopathy should not be considered a cause of tension- type headache.
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References

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TLDR
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TLDR
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TLDR
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