Advances in the pathophysiology of tension-type headache: From stress to central sensitization
@article{Chen2009AdvancesIT, title={Advances in the pathophysiology of tension-type headache: From stress to central sensitization}, author={Yaniv Chen}, journal={Current Pain and Headache Reports}, year={2009}, volume={13}, pages={484-494} }
Tension-type headache (TTH) is the most common and most socioeconomically costly headache. Yet our knowledge regarding TTH pathophysiological mechanisms is still in its early stages. Psychological stress and weak coping mechanisms may initiate and propagate physiological pain via activation of second messengers in downstream substrates involved in pain. It seems that peripheral mechanisms are predominant in the episodic type (ETTH), whereas central mechanisms are involved in the chronic type…
61 Citations
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A deeper understanding of the immune system's role in the pathophysiological process and modulation of chronic pain could be a potential target for developing therapies in managing chronic pain.
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The importance of excluding chronic neuropathic pain and recognizing CS as the main component using a top-down approach to target the best pharmacological and non-pharmacological treatments is evident.
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The cholinergic neurotransmitter system in the pathophysiology of various forms of headaches is reviewed and the ACh-dependent mechanisms of the anticephalalgia action of pharmacological and nonpharmacological approaches used for the headache treatment are discussed.
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Neurotrophic factors in tension-type headache Fatores neurotróficos na cefaleia do tipo tensional
- Biology, Psychology
- 2015
It is reasonable to hypothetize that NF may be involved in TTH pathogenesis, and may play a role in nociception by regulating peripheral sensitivity of nocICEptors and by modulating the central processing of nOCiceptive information.
Neurotrophic factors in tension-type headache.
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- 2015
It is suggested that the serum levels of NF are not altered in TTH, and depression and anxiety scores as well as headache impact did not correlate with NF levels.
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In the pathophysiology of tension headache, both central and peripheral mechanisms are involved, which can potentially be modified by non-pharmacological and neuromodulation techniques.
Epidemiology of Tension-type Headache
- Psychology, MedicineCurrent pain and headache reports
- 2010
This review will focus on the epidemiologies of episodic and chronic TTH in various age groups, factors associated with progression and remission, comorbidities, and the burden of TTH.
Osteopathic Manipulative Treatment in Tension Headaches
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A case of tension headache initially non-responsive to pain medication but resolved with osteopathic manipulative treatment and lifestyle modifications is presented.
An unusual cause of symptomatic tension-type headache: Hypertrophic branchial myopathy
- MedicineNeurology
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Future studies are needed to define parameters and estimate the prevalence of this entity among those with tension-type headache, and hypertrophic branchial myopathy should not be considered a cause of tension- type headache.
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