Advances in the pathogenesis of Goodpasture's disease: from epitopes to autoantibodies to effector T cells.

Abstract

Goodpasture's disease, an "organ-specific" autoimmune disease is manifest by rapidly progressive glomerulonephritis and pulmonary hemorrhage. Studies into the pathogenesis of this disease have shed light on the autoantigen (the non-collagenous domain of the alpha3 chain of type IV collagen, alpha3(IV)NC1) and its epitopes, as well as the involvement of… (More)
DOI: 10.1016/j.jaut.2008.04.005

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