Advances in the management of early pregnancy loss

  title={Advances in the management of early pregnancy loss},
  author={Andrea Henkel and Kate A. Shaw},
  journal={Current Opinion in Obstetrics and Gynecology},
  • A. Henkel, K. Shaw
  • Published 1 December 2018
  • Medicine
  • Current Opinion in Obstetrics and Gynecology
Purpose of review To describe recent advances in management of early pregnancy loss. Recent findings Addition of mifepristone to current protocols for medical management of miscarriage increases effectiveness of a single dose of misoprostol and significantly reduces subsequent aspiration procedures. Women with an incomplete evacuation after medical management may be treated expectantly with similar rates of complete expulsion compared with surgical management at 6 weeks. As cytogenetic analysis… 
5 Citations
A prospective observational study of the follow-up of medical management of early pregnancy failure
Findings of the study showed the check curettage rate of 37.8%.
Conservative management for retained products of conception after less than 22 weeks of gestation
The aim of the study was to investigate the efficacy of conservative treatment in cases of retained products of conception (RPOC) with a preceding pregnancy of less than 22 weeks and to assess
Changes in the level of fetoplacental complex hormones in pregnant women with miscarriage
Evidence of a pronounced hormonal abnormality of the placenta, and hence a marker of fetoplacental dysfunction, which on the background of miscarriage develops at the early stages and continues to progress with the course of pregnancy is obtained.
The role of the humanoid diagram teaching strategy in the nursing of women undergoing caesarean section.
H humanoid diagram teaching strategy helps to reduce the complication rate following caesarean section, improves the postoperative pain levels and adverse moods, and improves the patients' satisfaction levels with the nursing interventions, so it is of positive significance for the doctor-patient relationship.
To operate or to wait? Doppler indices as predictors for medical termination for first trimester missed abortion
Department of Obstetrics andGynecology, College ofMedicine, Al-MustansiriyahUniversity, 10052 Iraq Department of Radiology, College ofMedicine, Al-MustansiriyahUniversity, 10052 Iraq Ministry of


A Comparison of Medical Management with Misoprostol and Surgical Management for Early Pregnancy Failure
The efficacy, safety, and acceptability of this treatment in a large, randomized trial of misoprostol in women with a first-trimester pregnancy failure were assessed.
Mifepristone Pretreatment for the Medical Management of Early Pregnancy Loss
Pretreatment with mifepristone followed by treatment with misoprostol resulted in a higher likelihood of successful management of first‐trimester pregnancy loss than treatment with MISProstol alone.
Management of miscarriage: expectant, medical, or surgical? Results of randomised controlled trial (miscarriage treatment (MIST) trial)
The incidence of gynaecological infection after surgical, expectant, and medical management of first trimester miscarriage is low, and no evidence exists of a difference by the method of management, but significantly more unplanned admissions and unplanned surgical curettage occurred after expectant management and medicalManagement.
Systematic review and meta-analysis of intrauterine adhesions after miscarriage: prevalence, risk factors and long-term reproductive outcome.
Although this review does not allow strong clinical conclusions on treatment management, it signals an important clinical problem as the number of dilatation and curettage procedures seemed to be the main driver behind these associations.
Factors influencing women's preferences for subsequent management in the event of incomplete evacuation of the uterus after misoprostol treatment for miscarriage
Patients preferences should be addressed when counselling patients with an incomplete miscarriage after misoprostol treatment, and the importance of each attribute was analysed, and preference heterogeneity was investigated through latent-class analysis.
MisoREST: surgical versus expectant management in women with an incomplete evacuation of the uterus after misoprostol treatment for miscarriage: a randomized controlled trial.
In women suspected of incomplete evacuation of the uterus after misoprostol, curettage is more effective than Expectant management, however, expectant management is equally safe and prevents curettages for most of the women.
Interpregnancy interval following miscarriage and adverse pregnancy outcomes: systematic review and meta-analysis
This is the first systematic review and meta-analysis providing clear evidence that an IPI of less than 6 months following miscarriage is not associated with adverse outcomes in the next pregnancy.