Advances in the enzymology of glutamine synthesis.

  • Daniel L. Purich
  • Published 1998 in
    Advances in enzymology and related areas of…


Meister's proposal of a gamma-glutamyl-P intermediate in the glutamine synthetase reaction set the scene for understanding how the stepwise activation of the carboxyl group greatly increased its susceptibility toward nucleophilic attack and amide bond synthesis. Topics covered in this review include: the discovery of the enzymatic synthesis of glutamine… (More)