Advances in the characterization of RNA‐binding proteins

  title={Advances in the characterization of RNA‐binding proteins},
  author={Domenica Marchese and Natalia Sanchez de Groot and Nieves Lorenzo Gotor and Carmen Maria Livi and Gian Gaetano Tartaglia},
  booktitle={Wiley interdisciplinary reviews. RNA},
From transcription, to transport, storage, and translation, RNA depends on association with different RNA-binding proteins (RBPs). Methods based on next-generation sequencing and protein mass-spectrometry have started to unveil genome-wide interactions of RBPs but many aspects still remain out of sight. How many of the binding sites identified in high-throughput screenings are functional? A number of computational methods have been developed to analyze experimental data and to obtain insights… CONTINUE READING