Advances in the bioconversion mechanism of lovastatin to wuxistatin by Amycolatopsis sp. CGMCC 1149

@article{Zong2012AdvancesIT,
  title={Advances in the bioconversion mechanism of lovastatin to wuxistatin by Amycolatopsis sp. CGMCC 1149},
  author={H. Zong and B. Zhuge and H. Fang and Y. Cao and Linchun Mu and Weilai Fu and Jian Song and J. Zhuge},
  journal={Applied Microbiology and Biotechnology},
  year={2012},
  volume={97},
  pages={599-609}
}
Wuxistatin, a novel statin and more potent than lovastatin, was converted from lovastatin by Amycolatopsis sp. (CGMCC 1149). Product I, an intermediate product, was found in the fermentation broth, and the structure analysis showed that product I had an additional hydroxyl group at the methyl group attached to C3 compared to lovastatin, which indicates that product I is one isomer of wuxistatin. Isotope tracing experiment proved that hydroxyl group of wuxistatin was provided by product I and… Expand
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