Advances in the Inhibitors of Janus Kinase

  title={Advances in the Inhibitors of Janus Kinase},
  author={Junhang Jiang and Xiaoying Wang and Yv Zhang and Yi Jin and Jun Lin},
  journal={Medicinal Chemistry},
The janus kinases (JAKs) comprise an important class of non-receptor protein tyrosine kinases. Cytokine and receptor binding can cause the activation of JAKs, and then activate the "signal transcripts and transcriptional activator”, making JAK enter the nucleus to induce target gene expression. JAKs regulate inflammatory diseases, bone marrow hyperplasia and a variety of malignant tumours. Using JAKs inhibitors as the therapy for organ transplantation and immune disease has a very important… 
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