Advances in tenascin-C biology

  title={Advances in tenascin-C biology},
  author={Kim S. Midwood and Thomas Hussenet and Beno{\^i}t Langlois and Gertraud Orend},
  booktitle={Cellular and Molecular Life Sciences},
Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different roles that mediate both inflammatory and fibrotic processes to enable effective tissue repair. In the last decade, emerging evidence has demonstrated a vital role for tenascin-C in cardiac and arterial injury, tumor angiogenesis and metastasis, as well as in modulating stem cell behavior. Here we highlight the… CONTINUE READING