Advances in targeting the vacuolar proton-translocating ATPase (V-ATPase) for anti-fungal therapy

@inproceedings{Hayek2014AdvancesIT,
  title={Advances in targeting the vacuolar proton-translocating ATPase (V-ATPase) for anti-fungal therapy},
  author={Summer Raines Hayek and Samuel A Lee and Karlett J Parra},
  booktitle={Front. Pharmacol.},
  year={2014}
}
Vacuolar proton-translocating ATPase (V-ATPase) is a membrane-bound, multi-subunit enzyme that uses the energy of ATP hydrolysis to pump protons across membranes. V-ATPase activity is critical for pH homeostasis and organelle acidification as well as for generation of the membrane potential that drives secondary transporters and cellular metabolism. V-ATPase is highly conserved across species and is best characterized in the model fungus Saccharomyces cerevisiae. However, recent studies in… CONTINUE READING