Advances in systems biology are enhancing our understanding of disease and moving us closer to novel disease treatments

@article{Schadt2009AdvancesIS,
  title={Advances in systems biology are enhancing our understanding of disease and moving us closer to novel disease treatments},
  author={Eric E. Schadt and Bin Zhang and Jun Zhu},
  journal={Genetica},
  year={2009},
  volume={136},
  pages={259-269}
}
With tens of billions of dollars spent each year on the development of drugs to treat human diseases, and with fewer and fewer applications for investigational new drugs filed each year despite this massive spending, questions now abound on what changes to the drug discovery paradigm can be made to achieve greater success. The high rate of failure of drug candidates in clinical development, where the great majority of these drugs fail due to lack of efficacy, speak directly to the need for more… CONTINUE READING

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