Advances in product release strategies and impact on bioprocess design.

  title={Advances in product release strategies and impact on bioprocess design.},
  author={Bangaru Balasundaram and S. T. L. Harrison b Sue. Harrison and Daniel G Bracewell},
  journal={Trends in biotechnology},
  volume={27 8},
Intracellular products such as recombinant insulin, which are typically produced in microbial host cells, demand a product release step to remove them from the cell. How this is performed determines the quantity of released contaminants, the particle size distribution of cell debris and the physical properties of the resultant process stream, which all impact on the performance of the downstream operations. Thus, achieving selective release of the desired product is crucial for improving the… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 22 extracted citations


Publications referenced by this paper.
Showing 1-10 of 77 references

2008)A study of the influence of yeast cell debris on protein and a-glucosidase adsorption at various zones within the expanded bed using in-bed sampling

  • B Balasundaram
  • Biotechnol. Bioeng
  • 2008

Comparative evaluation of different cell disruption methods for the release of recombinant hepatitis B core antigen from Escherichia coli

  • Ho, C.W
  • Biotechnol. Bioprocess Eng
  • 2008

Influence of the extent of disruption of bakers’ yeast on protein adsorption in expanded beds

  • Balasundaram, S.T.L.B. andHarrison
  • J. Biotechnol
  • 2008

Similar Papers

Loading similar papers…