Advances in overgrowth syndromes: clinical classification to molecular delineation in Sotos syndrome and Beckwith-Wiedemann syndrome.

@article{Cytrynbaum2005AdvancesIO,
  title={Advances in overgrowth syndromes: clinical classification to molecular delineation in Sotos syndrome and Beckwith-Wiedemann syndrome.},
  author={Cheryl Cytrynbaum and Adam P C Smith and Tamar Rubin and Rosanna A Weksberg},
  journal={Current opinion in pediatrics},
  year={2005},
  volume={17 6},
  pages={740-6}
}
PURPOSE OF REVIEW The clinical importance of overgrowth syndromes in the pediatric patient population has been increasingly recognized during the past decade, but clinical overlap among overgrowth syndromes often makes diagnostic categorization difficult. Advances in the molecular delineation of overgrowth syndromes in recent years have furthered our knowledge of the phenotypic spectrum of this group of conditions. This review focuses on developments in our understanding of the molecular… CONTINUE READING