Advances in mosquito allergy

@article{Peng2007AdvancesIM,
  title={Advances in mosquito allergy},
  author={Z. Peng and F. Simons},
  journal={Current Opinion in Allergy and Clinical Immunology},
  year={2007},
  volume={7},
  pages={350–354}
}
  • Z. Peng, F. Simons
  • Published 2007
  • Medicine
  • Current Opinion in Allergy and Clinical Immunology
Purpose of reviewAllergic reactions, including severe local and systemic reactions to mosquito bites, are immunological in nature, and involve immunoglobulin E, immunoglobulin G, and T-lymphocyte-mediated hypersensitivities in response to allergens in mosquito saliva. Naturally acquired desensitization to mosquito saliva may occur during childhood or during long-term exposure to mosquitoes. Due to the lack of availability of mosquito salivary preparations for use in skin tests and in-vitro… Expand
Exposure to Aedes aegypti Bites Induces a Mixed-Type Allergic Response following Salivary Antigens Challenge in Mice
TLDR
A murine model of adjuvant-free systemic allergy induced by natural exposure to mosquito bites shows that A. aegypti bites trigger an atypical allergic reaction, with some classical cellular and soluble Th2 components in the lung, but also systemic Th1 and Th2 antibody isotypes and no change in either the respiratory pattern or the trachea responsiveness to agonist. Expand
Characteristics of Asian mosquito saliva allergens for specific diagnoses and effective therapies.
  • S. Jeon
  • Medicine
  • Current protein & peptide science
  • 2019
TLDR
Improve the diagnosis and treatment of patients with severe sensitivity to mosquito allergy by predicting the characteristics of East Asian mosquito allergy, presenting the future direction of production of recombinant allergens, and understanding the difference between East and West. Expand
Type I hypersensitivity promotes Aedes aegypti blood feeding
TLDR
It is suggested that mosquito saliva-induced type I hypersensitivity promotes blood feeding but that this may be independent from histamine or histamine signaling. Expand
Comparative identification of protein profiles and major allergens of saliva, salivary gland and whole body extracts of mosquito species in Thailand.
TLDR
It was concluded that mosquito saliva was the best source of allergens in Thailand, and the identificstion of major allergens should facilitate the production of specific recombinant allergens and contribute to improvement in the diagnosis and specific immunotherapy of Thai mosquito bite allergy patients. Expand
Novel salivary gland allergens from tropical mosquito species and IgE reactivity in allergic patients☆
TLDR
The majority of mosquito-allergic subjects who live in the tropics have IgE reactivity to these allergens, and the development of diagnostic tests, component-resolved diagnostics, and future immunotherapy for mosquito allergy in tropical countries are paved. Expand
Basophil activation by mosquito extracts in patients with hypersensitivity to mosquito bites
TLDR
Results indicate that basophils and/or mast cells activated by mosquito bites may be involved in initiation and development of severe skin reactions to mosquito bites in HMB. Expand
Mosquito allergy: a novel strong prognostic symptom of outcome after allogeneic hematopoietic transplantation
TLDR
The prognosis and immune profile of patients who had mosquito allergy after allo-HCT were investigated and it was revealed that even if adjusted by age and disease risk, the HMB group tended to have a lower OS hazard risk than the control group. Expand
[Hypersensitivity to mosquito bite manifested as Skeeter síndrome].
TLDR
Two cases of patients with hypersensitivity reactions to mosquito bites, which were evaluated in the center presenting positive skin tests are reported, supported by the identification of specific IgE by skin testing. Expand
Beat the bite: pathophysiology and management of itch in mosquito bites
TLDR
Individuals’ susceptibility to being bitten relies on factors that may be altered by genetics, as certain immune-related loci have been associated with mosquito bite trait characteristics and certain disease states may exaggerate the response to mosquito bites. Expand
Mosquito Hypersensitivity: Clinical Updates
TLDR
This chapter will focus on the clinical, immunologic, diagnostic, and therapeutic aspects of mosquito bite hypersensitivity, a common affliction for both children and adults. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 35 REFERENCES
Mosquito Allergy: Immune Mechanisms and Recombinant Salivary Allergens
  • Z. Peng, F. Simons
  • Medicine, Biology
  • International Archives of Allergy and Immunology
  • 2004
TLDR
Recombinant mosquito saliva allergens with biological activity are being developed and will significantly improve diagnosis of mosquito allergy and eventually will also improve specific immunotherapy for patients with systemic reactions to mosquito bites. Expand
Role of recombinant mosquito salivary allergens in the diagnosis of individuals with allergic reactions to mosquito bites
TLDR
Investigation of the role of 3 recombinant Aedes aegypti salivary allergens, expressed in the laboratory using a baculovirus/insect cell system, and the results with mosquito saliva-based immunoassays found they are sensitive and specific for the diagnosis of mosquito allergy. Expand
Immune responses to mosquito saliva in 14 individuals with acute systemic allergic reactions to mosquito bites.
TLDR
Acute systemic allergic reactions to mosquito bites involve mosquito saliva-specific IgE and can be characterized immunologically, according to a direct ELISA developed. Expand
Evidence for natural desensitization to mosquito salivary allergens: mosquito saliva specific IgE and IgG levels in children.
  • Z. Peng, M. K. Ho, Caihe Li, F. Simons
  • Medicine
  • Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 2004
TLDR
Based on the presence of mosquito saliva specific antibodies, exposed infants and young children are at increased risk of having allergic reactions to mosquito bites, suggesting that natural desensitization may occur. Expand
Efficacy and safety of specific immunotherapy to mosquito bites.
TLDR
S.I.T in mosquito bite allergy appears to be effective and safe in the treatment of both cutaneous and respiratory symptoms in patients having strong local immediate and delayed reactions with in many cases also an allergic rhinitis. Expand
Mosquito bite anaphylaxis: immunotherapy with whole body extracts.
TLDR
Immunotherapy with whole body mosquito extracts is a viable treatment option that can play a role in patients with mosquito bite-induced anaphylaxis and may also result in severe side effects and one must determine the benefit versus risks for each individual patient. Expand
Hypersensitivity to mosquito bites: a unique pathogenic mechanism linking Epstein-Barr virus infection, allergy and oncogenesis.
  • H. Asada
  • Biology, Medicine
  • Journal of dermatological science
  • 2007
TLDR
Clinical and laboratory studies have revealed that Hypersensitivity to mosquito bites occurs in association with natural killer (NK) cell lymphocytosis related to chronic Epstein-Barr virus (EBV) infection. Expand
Mosquito Allergy: Recombinant Mosquito Salivary Antigens for New Diagnostic Tests
  • F. Simons, Z. Peng
  • Medicine, Biology
  • International Archives of Allergy and Immunology
  • 2001
TLDR
Three recombinant mosquito salivary antigens from Aedes aegypti have been cloned, expressed, purified and characterized and will facilitate the diagnosis of mosquito allergy. Expand
Immunoblot analysis of salivary allergens in 10 mosquito species with worldwide distribution and the human IgE responses to these allergens.
BACKGROUND Most people develop skin reactions to mosquito bites, however, little is known about mosquito salivary allergens and the IgE responses to them. OBJECTIVES We sought to identify theseExpand
Characterization of Aedes communis, Aedes aegypti and Anopheles stephensi mosquito saliva antigens by immunoblotting.
TLDR
This study disclosed several immunogenic proteins in Aedes and Anopheles mosquito saliva and suggests that these proteins can also be allergenic in man. Expand
...
1
2
3
4
...