Advances in metal-induced oxidative stress and human disease.

@article{Jomov2011AdvancesIM,
  title={Advances in metal-induced oxidative stress and human disease.},
  author={Klaudia Jomov{\'a} and Mari{\'a}n Valko},
  journal={Toxicology},
  year={2011},
  volume={283 2-3},
  pages={
          65-87
        }
}
Detailed studies in the past two decades have shown that redox active metals like iron (Fe), copper (Cu), chromium (Cr), cobalt (Co) and other metals undergo redox cycling reactions and possess the ability to produce reactive radicals such as superoxide anion radical and nitric oxide in biological systems. Disruption of metal ion homeostasis may lead to oxidative stress, a state where increased formation of reactive oxygen species (ROS) overwhelms body antioxidant protection and subsequently… CONTINUE READING
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