Advances in liquid biopsy on-chip for cancer management: Technologies, biomarkers, and clinical analysis

  title={Advances in liquid biopsy on-chip for cancer management: Technologies, biomarkers, and clinical analysis},
  author={Amogha Tadimety and Andrew B. Closson and C. Li and S. Yi and T. Shen and J. Zhang},
  journal={Critical Reviews in Clinical Laboratory Sciences},
  pages={140 - 162}
  • Amogha Tadimety, Andrew B. Closson, +3 authors J. Zhang
  • Published 2018
  • Medicine, Biology
  • Critical Reviews in Clinical Laboratory Sciences
  • Abstract Liquid biopsy, as a minimally invasive method of gleaning insight into the dynamics of diseases through a patient fluid sample, has been growing in popularity for cancer diagnosis, prognosis, and monitoring. While many technologies have been developed and validated in research laboratories, there has also been a push to expand these technologies into other clinical settings and as point of care devices. In this article, we discuss and evaluate microchip-based technologies for… CONTINUE READING
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    Publications referenced by this paper.
    Liquid biopsy on chip: a paradigm shift towards the understanding of cancer metastasis.
    • 20
    • Open Access
    Implementing liquid biopsies into clinical decision making for cancer immunotherapy
    • 38
    • Open Access
    Size-selective collection of circulating tumor cells using Vortex technology.
    • 322
    • Open Access
    Future microfluidic and nanofluidic modular platforms for nucleic acid liquid biopsy in precision medicine.
    • 25
    • Open Access
    Liquid Biopsy for Cancer: Circulating Tumor Cells, Circulating Free DNA or Exosomes?
    • 98
    • Open Access
    Capture, release and culture of circulating tumor cells from pancreatic cancer patients using an enhanced mixing chip.
    • 167
    • Open Access
    Circulating tumor cells in breast cancer: detection systems, molecular characterization, and future challenges.
    • 148
    • Open Access