Advances in iron overload therapies. prospects for effective use of deferiprone (L1), deferoxamine, the new experimental chelators ICL670, GT56-252, L1NA11 and their combinations.

@article{Kontoghiorghes2005AdvancesII,
  title={Advances in iron overload therapies. prospects for effective use of deferiprone (L1), deferoxamine, the new experimental chelators ICL670, GT56-252, L1NA11 and their combinations.},
  author={George J Kontoghiorghes and Eleni Eracleous and Charalambos P Economides and Annita Kolnagou},
  journal={Current medicinal chemistry},
  year={2005},
  volume={12 23},
  pages={
          2663-81
        }
}
Effective new therapies and mechanisms have been developed for the targeting and prevention of iron overload and toxicity in thalassaemia and idiopathic haemochromatosis patients. A new era in the development of chelating drugs began with the introduction of deferiprone or L1, which as a monotherapy or in combination with deferoxamine can be used universally for effective chelation treatments, rapid iron removal, maintenance of low iron stores and prevention of heart and other organ damage… CONTINUE READING
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