Advances in helper-dependent adenoviral vector research.

  title={Advances in helper-dependent adenoviral vector research.},
  author={Mar{\'i}a de las Mercedes Segura and R. Alba and Assumpci{\'o} Bosch and Miguel Chill{\'o}n},
  journal={Current gene therapy},
  volume={8 4},
The immunogenicity and cytotoxicity associated with early generations of adenoviral vectors provided a strong incentive for the development of helper-dependent adenovirus, a last generation of adenoviral vectors that is devoid of all viral coding sequences. These vectors have shown to mediate longer high-level transgene expression in vivo with reduced toxicity and thus offer enormous potential for human gene therapy. In addition, they possess a considerably larger cloning capacity than… CONTINUE READING

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