Advances in genetic findings on attention deficit hyperactivity disorder

  title={Advances in genetic findings on attention deficit hyperactivity disorder},
  author={Anita Thapar and Kate Langley and Michael J. Owen and Michael C. O’Donovan},
  journal={Psychological Medicine},
  pages={1681 - 1692}
ABSTRACT Attention deficit hyperactivity disorder (ADHD) is a common, childhood-onset neurodevelopmental disorder with adverse consequences during adult life. Family, twin and adoption studies show that genetic factors contribute to the aetiology of ADHD and that environmental factors also play a role. Family and twin studies have shown the importance of genetic influences on continuity in ADHD over time and in accounting for the co-occurrence of ADHD and conduct disorder problems. In meta… 

An Overview on the Genetics of ADHD.

The evidence to date, suggests that examining gene-phenotype links and testing whether gene variants have modifying effects on the ADHD phenotype are important, and the contribution of gene-environment interplay to psychopathology is becoming increasingly recognised.

Insights into attention-deficit/hyperactivity disorder from recent genetic studies

Recent advances in quantitative and molecular genetic research from the past 5-10 years are summarized to anticipate further success with gene discovery, characterization of how the ADHD phenotype relates to other human traits and growing potential to use genomic risk factors for understanding clinical trajectories and for precision medicine approaches.

Fitting the pieces together: current research on the genetic basis of attention-deficit/hyperactivity disorder (ADHD)

The first genome-wide association studies (GWAS) of ADHD have been completed and although larger studies are still required to detect common risk variants, novel risk pathways are being suggested for ADHD.

Impact of the ADHD-susceptibility gene CDH13 on development and function of brain networks

Longitudinal analysis of the effects of genetic and family factors on attention deficit hyperactivity disorder

Previous studies suggest that both genetic and environmental factors contribute to variation in Attention Deficit Hyperactivity Disorder (ADHD) symptoms and their continuation. Family relationship

Neurotrophic factor‐related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high‐risk male population

  • A. ConnerC. Kissling J. Thome
  • Biology, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
One polymorphism within the exon of NTF3 showed a trend toward an association between the A‐allele and increased scores using both the retrospective childhood analysis Wender–Utah Rating Scale (WURS‐k) and the adult ADHD assessment Wender-Reimherr interview, however, this finding needs replication in a larger study with higher power.

Rare Copy Number Variation Discovery and Cross-Disorder Comparisons Identify Risk Genes for ADHD

Support for a role for rare CNVs in ADHD risk is provided and evidence for the existence of common underlying susceptibility genes for ADHD, ASD, and other neuropsychiatric disorders is reinforced.

Investigation of the serotonin 2C receptor gene in attention deficit hyperactivity disorder in UK samples

Investigation of the association between ADHD and two polymorphisms C-759T and G-697C in the promoter region of the HTR2C gene provides evidence that the G-allele of the G -697C H TR2C polymorphism may be involved in the development of ADHD.

Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder

The finding suggests that genetic variation in the promoter region of DAT1 may be a risk factor in the development of ADHD.

A role for neurotransmission and neurodevelopment in attention-deficit/hyperactivity disorder

Plausible biological hypotheses linked to neurotransmission and neurodevelopment in general and common to different psychiatric conditions need to be considered when defining candidate genes for ADHD association studies.



Genetic basis of attention deficit and hyperactivity

Advances in psychiatric genetics and current research interest in the genetics of ADHD should improve the understanding of aetiological factors and have an impact on treatment.

Refining the attention deficit hyperactivity disorder phenotype for molecular genetic studies

Current evidence suggests that for the purpose of identifying susceptibility genes for ADHD, parent and teachers should be used as informants and that focusing on the clinical diagnosis of ADHD is useful.

Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism.

Using affected-sib-pair analysis in 203 families to localize the first major susceptibility locus for ADHD to a 12-cM region on chromosome 16p13, this work suggests that variations in a gene on 16 p13 may contribute to common deficits found in both ADHD and autism.

The genetics of attention-deficit/hyperactivity disorder

Gene–environment interactions, which are as yet relatively understudied, are likely to be of importance in fully understanding the role of genes in ADHD and are discussed.

Toward guidelines for pedigree selection in genetic studies of attention deficit hyperactivity disorder

This paper shows that comorbidity with conduct disorder and persistence of ADHD into adolescence are useful for molecular genetic studies because (1) they have much higher empirical λ values and (2) they affect a substantial minority of ADHD patients.

Attention-Deficit/Hyperactivity Disorder Endophenotypes

Examining the comorbidity of ADHD-related behaviours and conduct problems using a twin study design

Background Although attention-deficit hyperactivity disorder (ADHD) and conduct disorder (CD) frequently co-occur, the underlying mechanisms for this comorbidity are not well understood. Aims To

A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy.

A novel association was identified between ADHD, the intron 8 polymorphism, and a specific risk haplotype in both English and Taiwanese samples, and interaction between DAT1 genotypes and maternal use of alcohol during pregnancy suggests that Dat1 moderates the environmental risk and has implications for the prevention of ADHD.

Meta-analysis of family-based association studies between the dopamine transporter gene and attention deficit hyperactivity disorder

The meta-analysis showed no significant association between ADHD and the DAT gene, but an important between-samples heterogeneity, and the different biases detected herein probably explain the initial impression of a significant impact of the Dat gene on hyperactivity.