Advances in genetic findings on attention deficit hyperactivity disorder

@article{Thapar2007AdvancesIG,
  title={Advances in genetic findings on attention deficit hyperactivity disorder},
  author={Anita Thapar and Kate Langley and Michael J. Owen and Michael C. O'Donovan},
  journal={Psychological Medicine},
  year={2007},
  volume={37},
  pages={1681 - 1692}
}
ABSTRACT Attention deficit hyperactivity disorder (ADHD) is a common, childhood-onset neurodevelopmental disorder with adverse consequences during adult life. Family, twin and adoption studies show that genetic factors contribute to the aetiology of ADHD and that environmental factors also play a role. Family and twin studies have shown the importance of genetic influences on continuity in ADHD over time and in accounting for the co-occurrence of ADHD and conduct disorder problems. In meta… Expand
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Recent advances in quantitative and molecular genetic research from the past 5-10 years are summarized to anticipate further success with gene discovery, characterization of how the ADHD phenotype relates to other human traits and growing potential to use genomic risk factors for understanding clinical trajectories and for precision medicine approaches. Expand
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The first genome-wide association studies (GWAS) of ADHD have been completed and although larger studies are still required to detect common risk variants, novel risk pathways are being suggested for ADHD. Expand
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Neurotrophic factor‐related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high‐risk male population
  • A. Conner, C. Kissling, +7 authors J. Thome
  • Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
TLDR
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Association Study of 10 Genes Encoding Neurotrophic Factors and Their Receptors in Adult and Child Attention-Deficit/Hyperactivity Disorder
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The data suggest that variations in NTFs might be involved in the genetic susceptibility to ADHD, support the contribution of the CNTFR locus as a predisposition factor for the disorder, and suggest that NTF3 and NTRK2 might be involvement in the molecular basis of the age-dependent changes in ADHD symptoms throughout life span. Expand
Rare Copy Number Variation Discovery and Cross-Disorder Comparisons Identify Risk Genes for ADHD
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Support for a role for rare CNVs in ADHD risk is provided and evidence for the existence of common underlying susceptibility genes for ADHD, ASD, and other neuropsychiatric disorders is reinforced. Expand
Investigation of the serotonin 2C receptor gene in attention deficit hyperactivity disorder in UK samples
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Investigation of the association between ADHD and two polymorphisms C-759T and G-697C in the promoter region of the HTR2C gene provides evidence that the G-allele of the G -697C H TR2C polymorphism may be involved in the development of ADHD. Expand
Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder
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The finding suggests that genetic variation in the promoter region of DAT1 may be a risk factor in the development of ADHD. Expand
A role for neurotransmission and neurodevelopment in attention-deficit/hyperactivity disorder
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Plausible biological hypotheses linked to neurotransmission and neurodevelopment in general and common to different psychiatric conditions need to be considered when defining candidate genes for ADHD association studies. Expand
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