Advances in genetic findings on attention deficit hyperactivity disorder

@article{Thapar2007AdvancesIG,
  title={Advances in genetic findings on attention deficit hyperactivity disorder},
  author={Anita Thapar and Kate Langley and Michael J. Owen and Michael C. O’Donovan},
  journal={Psychological Medicine},
  year={2007},
  volume={37},
  pages={1681 - 1692}
}
ABSTRACT Attention deficit hyperactivity disorder (ADHD) is a common, childhood-onset neurodevelopmental disorder with adverse consequences during adult life. Family, twin and adoption studies show that genetic factors contribute to the aetiology of ADHD and that environmental factors also play a role. Family and twin studies have shown the importance of genetic influences on continuity in ADHD over time and in accounting for the co-occurrence of ADHD and conduct disorder problems. In meta… 

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TLDR
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TLDR
Recent advances in quantitative and molecular genetic research from the past 5-10 years are summarized to anticipate further success with gene discovery, characterization of how the ADHD phenotype relates to other human traits and growing potential to use genomic risk factors for understanding clinical trajectories and for precision medicine approaches.

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TLDR
The first genome-wide association studies (GWAS) of ADHD have been completed and although larger studies are still required to detect common risk variants, novel risk pathways are being suggested for ADHD.

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Previous studies suggest that both genetic and environmental factors contribute to variation in Attention Deficit Hyperactivity Disorder (ADHD) symptoms and their continuation. Family relationship

Neurotrophic factor‐related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high‐risk male population

  • A. ConnerC. Kissling J. Thome
  • Biology, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
TLDR
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Rare Copy Number Variation Discovery and Cross-Disorder Comparisons Identify Risk Genes for ADHD

TLDR
Support for a role for rare CNVs in ADHD risk is provided and evidence for the existence of common underlying susceptibility genes for ADHD, ASD, and other neuropsychiatric disorders is reinforced.

Investigation of the serotonin 2C receptor gene in attention deficit hyperactivity disorder in UK samples

TLDR
Investigation of the association between ADHD and two polymorphisms C-759T and G-697C in the promoter region of the HTR2C gene provides evidence that the G-allele of the G -697C H TR2C polymorphism may be involved in the development of ADHD.

Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder

TLDR
The finding suggests that genetic variation in the promoter region of DAT1 may be a risk factor in the development of ADHD.

A role for neurotransmission and neurodevelopment in attention-deficit/hyperactivity disorder

TLDR
Plausible biological hypotheses linked to neurotransmission and neurodevelopment in general and common to different psychiatric conditions need to be considered when defining candidate genes for ADHD association studies.
...

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