Advances in enzymatic transformation of penicillins to 6-aminopenicillanic acid (6-APA).

@article{Parmar2000AdvancesIE,
  title={Advances in enzymatic transformation of penicillins to 6-aminopenicillanic acid (6-APA).},
  author={A Parmar and Harendra Kumar and Satwinder Singh Marwaha and John Fitzgerald Kennedy},
  journal={Biotechnology advances},
  year={2000},
  volume={18 4},
  pages={289-301}
}
This article elaborates on the important recent developments in the enzymatic transformation of penicillins to 6-aminopenicillanic acid (6-APA), which is the basic raw material for the industrial production of semisynthetic penicillins such as amoxycillin and ampicillin. Particular emphasis is placed on the improvements in purification, stability, and immobilization of the enzymes, (i.e. penicillin acylases) used for these transformations. 

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