Advances in dihydroetorphine: From analgesia to detoxification

  title={Advances in dihydroetorphine: From analgesia to detoxification},
  author={Qin Bo-Yi},
  journal={Drug Development Research},
  • Qin Bo-Yi
  • Published 1 October 1996
  • Medicine, Biology
  • Drug Development Research
Dihydroetorphine is the first narcotic analgesic successfully developed and approved for production in China. As an analgesic, it has been used safely and effectively in clinical practice for 12 years. In recent years, it has been used successfully for substitution therapy in detoxification from opiates. As a drug for detoxification from opiates, the main advantages of DHE are its quick onset of effect and thorough control of the abstinence symptoms. DHE can detoxify heroin dependence in 7–10… 
5 Citations

The Physiological Basis Of Drug Addiction

  • Biology
  • 2009
Dopamine appears to harbor the largest effect and its action is characterized, and cAMP-dependent protein kinase (PKA) phosphorylates cAMP response element binding protein (CREB), a transcription factor, which induces the synthesis of certain genes including C-Fos.



[Analgesic and other CNS depressive effects of dihydroetorphine (author's transl)].

  • M. HuangB. Qin
  • Biology, Medicine
    Zhongguo yao li xue bao = Acta pharmacologica Sinica
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DHE, resembling morphine, caused Straub's tail and a marked increase in locomotor activity in mice, sedation in dogs and monkeys, and miosis in dogs, and in contrast to morphine, DHE did not induce emesis in dogs.

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  • M. HuangB. Qin
  • Medicine, Biology
    Zhongguo yao li xue bao = Acta pharmacologica Sinica
  • 1982
The ability of producing physical dependence of dihydroetorphine was compared with that of morphine in mice and monkeys and suggest that DHE produces a relatively low physical dependence in animals.

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  • Medicine
    Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • 1991
Within certain range, increase in dose was able to enhance its analgesic effect and reduce drug resistance, and the pain-relief in patients with bladder cancer was poor.

Novel analgesics and molecular rearrangements in the morphine-thebaine group. 3. Alcohols of the 6,14-endo-ethenotetrahydrooripavine series and derived analogs of N-allylnormorphine and -norcodeine.

Since the demethylation of codeine derivatives to the corresponding derivatives of morphine almost always results in an appreciable increase in analgesic activity, most of the alcohols of structures I and I1 were converted into the related phenols.