Advances in closed-loop deep brain stimulation devices
@article{Parastarfeizabadi2017AdvancesIC, title={Advances in closed-loop deep brain stimulation devices}, author={Mahboubeh Parastarfeizabadi and Abbas Z. Kouzani}, journal={Journal of NeuroEngineering and Rehabilitation}, year={2017}, volume={14} }
BackgroundMillions of patients around the world are affected by neurological and psychiatric disorders. Deep brain stimulation (DBS) is a device-based therapy that could have fewer side-effects and higher efficiencies in drug-resistant patients compared to other therapeutic options such as pharmacological approaches. Thus far, several efforts have been made to incorporate a feedback loop into DBS devices to make them operate in a closed-loop manner.MethodsThis paper presents a comprehensive…
113 Citations
N-of-1 Trials for Closed-Loop Deep Brain Stimulation Devices.
- Medicine, PsychologyEthics & human research
- 2020
It is argued that an N-of-1 trial design could provide beneficial phenomenological data about the potential risks of harm to properly inform the use of closed-loop DBS devices.
Model-Based Evaluation of Closed-Loop Deep Brain Stimulation Controller to Adapt to Dynamic Changes in Reference Signal
- Computer ScienceFront. Neurosci.
- 2019
Close-loop deep brain stimulation may be effective in suppressing parkinsonian symptoms with stimulation parameters that require less energy and evoke fewer side effects than open loop DBS, however, the design of CL DBS comes with several challenges including the selection of an appropriate biomarker reflecting the symptoms of PD, setting a suitable reference signal, and implementing a controller to adapt to dynamic changes in the reference signal.
Developments in Deep Brain Stimulators for Successful Aging Towards Smart Devices—An Overview
- Computer ScienceFrontiers in Aging
- 2022
Different methods, using ambient energy scavenging, that offer alternative solutions to prolong the battery life of the DBS device are showcased, geared towards a low maintenance, semi-autonomous, and less disruptive device to be used by the elderly patient suffering from motor and cognitive disorders.
Toward a closed-loop deep brain stimulation in Parkinson's disease using local field potential in parkinsonian rat model.
- Computer ScienceMedical hypotheses
- 2019
Ethical Implications of Closed Loop Brain Device: 10-Year Review
- MedicineMinds and Machines
- 2020
The aim of this study is to provide an overview of the ethical implications specific to the therapeutic goals of closed loop brain implants, and analyze the related work qualitatively and quantitatively so as to help readers in understanding the various ethical implications of closed Loop brain implants.
Toward adaptive deep brain stimulation in Parkinson's disease: a review.
- MedicineNeurodegenerative disease management
- 2018
This review focuses on the major areas that are essential in driving technological advances for the various aDBS schemes, both for closed-loop adaption and spatialAdaption, and their challenges, prospects and progress so far.
Multi-Disease Deep Brain Stimulation
- Computer ScienceIEEE Access
- 2020
The design and evaluation of a multi-disease closed-loop DBS device that can sense multiple brain biomarkers, detect a disorder, and adaptively deliver electrical stimulation pulses based on the disease state is presented.
Computationally efficient algorithms and implementations of adaptive deep brain stimulation systems for Parkinson's disease
- Computer Science
- 2018
Four system implementations that could facilitate DBS adaptation either in the form of closed-loop DBS or spatial adaptation are proposed, which developed the first known PD detection and monitoring processor and proposed a framework for adapting DBS based on a critic-actor control approach.
Closed-loop Modulation of the Self-regulating Brain: A Review on Approaches, Emerging Paradigms, and Experimental Designs
- PsychologyNeuroscience
- 2022
Self-Tuning Deep Brain Stimulation Controller for Suppression of Beta Oscillations: Analytical Derivation and Numerical Validation
- EngineeringFrontiers in Neuroscience
- 2020
Compared to proportional feedback methods without gain adaptation, the proposed adaptive controller was able to suppress beta-band oscillations with less power consumption, even as the properties of the controlled system evolve over time due to alterations in the target for beta suppression, beta fluctuations and variations in the electrode impedance.
References
SHOWING 1-10 OF 178 REFERENCES
Closed loop deep brain stimulation: an evolving technology
- MedicineAustralasian Physical & Engineering Sciences in Medicine
- 2014
This paper provides a study on the existing systems developed for closed loop deep brain stimulation and highlights the issues associated with CLDBS systems including feedback signal recording and processing, stimulation parameters setting, control algorithm, wireless telemetry, size, and power consumption.
A neurochemical closed-loop controller for deep brain stimulation: toward individualized smart neuromodulation therapies
- BiologyFront. Neurosci.
- 2014
A proof-of-principle closed-loop controller that characterizes DBS-evoked dopamine changes to adjust stimulation parameters in a rodent model of DBS is described, representing the initial steps toward achieving a “smart” neuroprosthetic system for treatment of neurologic and psychiatric disorders.
Closed-Loop Control of Deep Brain Stimulation: A Simulation Study
- MedicineIEEE Transactions on Neural Systems and Rehabilitation Engineering
- 2011
This computational study suggests the feasibility of closed-loop control of DBS amplitude to regulate the spectrum of the local field potentials and thereby normalize the aberrant pattern of neuronal activity present in tremor.
Closed-loop neuromodulation systems: next-generation treatments for psychiatric illness
- Psychology, MedicineInternational review of psychiatry
- 2017
The available closed-loop neuromodulation platforms, which have shown clinical efficacy in epilepsy and strong early results in movement disorders, are introduced and the strengths and limitations of these devices in the context of psychiatric illness are discussed.
Closed-Loop Deep Brain Stimulation Effects on Parkinsonian Motor Symptoms in a Non-Human Primate – Is Beta Enough?
- MedicineBrain Stimulation
- 2016
A Miniature Low-Power Multi-Biomarker-Based Brain Sensor for Closed-Loop DBS
- Engineering, BiologyIEEE Sensors Journal
- 2017
The design, fabrication, and in vitro evaluation of a miniature multi-biomarker-based neural sensor for closed-loop DBS of small laboratory animals is presented.
A miniature closed-loop deep brain stimulation device
- Engineering2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
- 2016
A miniature light-weight closed-loop deep brain stimulation (DBS) device that delivers on-demand stimulation current pulses by monitoring and analysing local field potentials and has been successfully validated by injecting a pre-recorded neural signal into its input, and collecting and analysed its output.
Conceptualization and validation of an open-source closed-loop deep brain stimulation system in rat
- BiologyScientific Reports
- 2015
The conceptualization and validation of a closed-loop DBS system using open-source hardware is demonstrated and it showed that closed- loop DBS significantly suppressed locomotion compared to no stimulation and required on average only 56% of the stimulation used in open-loopDBS to reach similar effects.
Adaptive deep brain stimulation (aDBS) controlled by local field potential oscillations
- MedicineExperimental Neurology
- 2013