Advances in chemotherapy against advanced or metastatic colorectal cancer.

@article{Omura2008AdvancesIC,
  title={Advances in chemotherapy against advanced or metastatic colorectal cancer.},
  author={Kenji Omura},
  journal={Digestion},
  year={2008},
  volume={77 Suppl 1},
  pages={13-22}
}
In the early 1990s, some prospective controlled trials revealed the superiority of chemotherapy for survival compared with best supportive care for advanced or metastatic colorectal carcinoma. Until recently, 5-fluorouracil (5-FU) and leucovorin (LV) were the standard therapies against advanced or metastatic colorectal cancer. Theoretically, LV should increase the antitumor activity of 5-FU, although this effect of LV addition has been controversial. A meta-analysis which analyzed 21 randomized… CONTINUE READING

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