Advances in blood pressure genomics.

@article{Munroe2013AdvancesIB,
  title={Advances in blood pressure genomics.},
  author={Patricia B. Munroe and Michael R. Barnes and Mark J. Caulfield},
  journal={Circulation research},
  year={2013},
  volume={112 10},
  pages={
          1365-79
        }
}
The elucidation of genes implicated in Mendelian forms of hypertension demonstrates rare variants with substantial effects are responsible, and often these genes lie within pathways managing sodium homeostasis. More recently with advances in affordable high-throughput genotyping strategies, multiple common genetic variants with modest effects on blood pressure (<1 mmHg systolic) have been discovered in the population. In aggregate, these common variants explain <3% of the variance of blood… 

Tables from this paper

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The advances in the detection of novel rare variants, genes, and/or pathways through the most promising approaches, and the recent statistical tests that have emerged to handle rare variants are reported.

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This study aimed to come up with a list of known genetic variants that may play a role in HTN, and found that antihypertensive medication responsiveness to epigenetics and regulatory networks may be improved by further research.

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This review describes the current state of the art of the genetic and molecular basis of blood pressure and hypertension and describes a new era of novel drug development, repurposing, and stratification in the management of hypertension.

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By reviewing blood pressure loci, it is aimed to determine how much potential the current observations have for future clinical utility and aid in the identification of potential druggable targets.

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

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Thirty new blood pressure– or hypertension-associated genetic regions in the general population are identified, including 3 rare missense variants in RBM47, COL21A1 and RRAS with larger effects than common variants.

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

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Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure–raising genetic variants on future cardiovascular disease risk.

Genetics of Blood Pressure: New Insights Into a Complex Trait.

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There is a need to better understand the genetic and mechanistic pathways underlying blood pressure regulation in order to identify new therapeutic targets for the prevention and treatment of high blood pressure.

Genetic screening in arterial hypertension

TLDR
The identification of genetic markers of drug response will enable the design of randomized controlled trials in much smaller series of patients than is currently possible, decreasing the costs and times from drug design to clinical use and ultimately providing patients and doctors with a larger number of tools to combat hypertension, the most important risk factor for cardiovascular disease.
...

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