Advances in blood pressure genomics.

  title={Advances in blood pressure genomics.},
  author={Patricia B. Munroe and Michael R. Barnes and Mark J. Caulfield},
  journal={Circulation research},
  volume={112 10},
The elucidation of genes implicated in Mendelian forms of hypertension demonstrates rare variants with substantial effects are responsible, and often these genes lie within pathways managing sodium homeostasis. More recently with advances in affordable high-throughput genotyping strategies, multiple common genetic variants with modest effects on blood pressure (<1 mmHg systolic) have been discovered in the population. In aggregate, these common variants explain <3% of the variance of blood… 

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