Advances in bispecific biotherapeutics for the treatment of cancer.

  title={Advances in bispecific biotherapeutics for the treatment of cancer.},
  author={Chad May and Puja Sapra and H. G. Gerber},
  journal={Biochemical pharmacology},
  volume={84 9},
Conventional monoclonal antibody (mAb) therapeutics interfering with cellular signaling of their respective target antigens are frequently limited in their ability to induce significant anti-tumor activities when administered as single agents in patients with solid tumors. To overcome these limitations, several new technologies are being developed to empower biotherapeutics and to improve their anti-tumor activities, while maintaining their high tumor selectivity and superior safety profiles… CONTINUE READING
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