Advances in biologically based models for respiratory tract uptake of inhaled volatiles.

@article{Medinsky1993AdvancesIB,
  title={Advances in biologically based models for respiratory tract uptake of inhaled volatiles.},
  author={Michele Medinsky and Julie S Kimbell and John B. Morris and Per Gerde and John H. Overton},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1993},
  volume={20 3},
  pages={265-72}
}
Physiologically based pharmacokinetic models for volatile organic chemicals typically describe the respiratory tract as a single compartment in which chemicals in the alveolar air space and the arterial blood are in instantaneous equilibrium. These models also assume that the distribution of chemical in the air-stream is uniform throughout the respiratory tract and that uptake is significant only in the alveolar region. A functional role for the upper respiratory tract in the uptake of volatile… CONTINUE READING

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