Advances in anti-viral immune defence: revealing the importance of the IFN JAK/STAT pathway

Abstract

Interferon-alpha (IFN-α) is a potent anti-viral cytokine, critical to the host immune response against viruses. IFN-α is first produced upon viral detection by pathogen recognition receptors. Following its expression, IFN-α embarks upon a complex downstream signalling cascade called the JAK/STAT pathway. This signalling pathway results in the expression of… (More)
DOI: 10.1007/s00018-017-2520-2

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