Advances in and Limitations of Up-and-down Methodology

@inproceedings{Warltier2007AdvancesIA,
  title={Advances in and Limitations of Up-and-down Methodology},
  author={David C. Warltier},
  year={2007}
}
Sequential design methods for binary response variables exist for determination of the concentration or dose associated with the 50% point along the dose–response curve; the up-anddown method of Dixon and Mood is now commonly used in anesthesia research. There have been important developments in statistical methods that (1) allow the design of experiments for the measurement of the response at any point (quantile) along the dose–response curve, (2) demonstrate the risk of certain statistical… CONTINUE READING

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