Advances in and Limitations of Up-and-down Methodology

  title={Advances in and Limitations of Up-and-down Methodology},
  author={David C. Warltier},
Sequential design methods for binary response variables exist for determination of the concentration or dose associated with the 50% point along the dose–response curve; the up-anddown method of Dixon and Mood is now commonly used in anesthesia research. There have been important developments in statistical methods that (1) allow the design of experiments for the measurement of the response at any point (quantile) along the dose–response curve, (2) demonstrate the risk of certain statistical… CONTINUE READING

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Introduction to Statistical Analysis, 4th edition

WJ Dixon, FJ Massey
New York, McGraw-Hill, • 1983
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Highly Influenced

Mood AM: A method for obtaining and analyzing sensitivity data

WJ Dixon
J Am Stat Assoc • 1948
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Sequential Analysis of Durham and Flournoy’s Biased Coin Design for Phase I Clinical Trials

M Stylianou
American University, Department of Mathematics and Statistics, College of Arts and Sciences, • 2000
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