Corpus ID: 33382178

Advances in ancient DNA studies

  title={Advances in ancient DNA studies},
  author={David Caramelli and Giampietro Lago},
The first aDNA studies used bacterial cloning to amplify small sequences retrieved from skins of animal and human mummies, and revealed the inefficient reaction kinetics of this technique (Higuchi et al., 1984; Paabo 1985, 1989). These studies demonstrated that the genetic material surviving in ancient specimens was often principally microbial or fungal in origin. Endogenous DNA was generally limited to very low concentrations of short, damaged fragments of multi-copy loci such as mitochondrial… Expand

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