Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint.

@article{Aguet2013AdvancesIA,
  title={Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint.},
  author={François Aguet and Costin N Antonescu and Marcel Mettlen and Sandra L Schmid and Gaudenz Danuser},
  journal={Developmental cell},
  year={2013},
  volume={26 3},
  pages={279-91}
}
Numerous endocytic accessory proteins (EAPs) mediate assembly and maturation of clathrin-coated pits (CCPs) into cargo-containing vesicles. Analysis of EAP function through bulk measurement of cargo uptake has been hampered due to potential redundancy among EAPs and, as we show here, the plasticity and resilience of clathrin-mediated endocytosis (CME). Instead, EAP function is best studied by uncovering the correlation between variations in EAP association to individual CCPs and the resulting… CONTINUE READING
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