Advances in allergen immunotherapy: Aiming for complete tolerance to allergens

@article{Akdis2015AdvancesIA,
  title={Advances in allergen immunotherapy: Aiming for complete tolerance to allergens},
  author={Cezmi A. Akdis and M{\"u}beccel Akdis},
  journal={Science Translational Medicine},
  year={2015},
  volume={7},
  pages={280ps6-280ps6}
}
Allergen-specific immunotherapy (AIT) has been used for more than 100 years as a tolerance-inducing therapy for allergic diseases and represents a potentially curative method of treatment. AIT functions through multiple mechanisms, including regulating T and B cell responses, changing antibody isotypes, and decreasing mediator release and migration of eosinophils, basophils, and mast cells to affected tissues. Despite the relative success of AIT, attempts are being made to improve this therapy… CONTINUE READING