Advances in Na(+)/I(-) symporter (NIS) research in the thyroid and beyond.

  title={Advances in Na(+)/I(-) symporter (NIS) research in the thyroid and beyond.},
  author={Orsolya Doh{\'a}n and Nancy Carrasco},
  journal={Molecular and cellular endocrinology},
  volume={213 1},
The Na(+)/I(-) symporter (NIS) is a plasma membrane glycoprotein that mediates active iodide uptake in the thyroid-the essential first step in thyroid hormone biosynthesis-and in other tissues, such as salivary and lactating mammary glands. Thyroidal radioiodide uptake has been used for over 60 years in the diagnosis and effective treatment of thyroid cancer and other diseases. However, the NIS cDNA was only isolated in 1996 by expression cloning in Xenopus laevis oocytes, marking the beginning… CONTINUE READING

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