Advances in Brief The S 387 Y Mutation of the Transforming Growth Factor-b Receptor Type I Gene Is Uncommon in Metastases of Breast Cancer and Other Common Types of Adenocarcinoma


Recently, mutations of the transforming growth factor-b receptor type I gene have been reported to occur at high frequency in breast cancer metastases, with all mutations being an identical C to A transversion at nucleotide 1160 of the gene (T. Chen et al., Cancer Res., 58: 4805–4810, 1998). This mutation would result in a serine to tyrosine substitution at… (More)

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