Advances in Brief The Phosphatidylinositol 3-Kinase Inhibitor Wortmannin Sensitizes Murine Fibroblasts and Human Tumor Cells to Radiation and Blocks Induction ofp 53 following DNA Damage 1

@inproceedings{Brendan2006AdvancesIB,
  title={Advances in Brief The Phosphatidylinositol 3-Kinase Inhibitor Wortmannin Sensitizes Murine Fibroblasts and Human Tumor Cells to Radiation and Blocks Induction ofp 53 following DNA Damage 1},
  author={Brendan and D. Price and Matthew and B. Youmell},
  year={2006}
}
  • Brendan, D. Price, +1 author B. Youmell
  • Published 2006
AT cells are extremely sensitive to ionizing radiation. Since the AT gene has homology to phosphatidylinositol 3 kinases(P13-kinases),wortman nm,a specificinhibitorofPI 3-kinase,wasusedtodetermineif P13-kinase activity regulates radiation sensitivity. Human and murine cells exposed to wortmannin alonedid not display significant cytotoxicity. Wortmanmn in combination with radiation was an effective radiosensitizer of munne NIH-3T3 fibroblasts, with a sensitizerenhancementratio of 1.8at 10… CONTINUE READING
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