Advances in Brief Systematic HRAS Amplification in Ovary-independent Mammary Tumors : Correlation with Progressively Anaplastic Phenotypes 1

Abstract

Progression of well differentiated rat mammary adenocarcinomas to very anaplastic phenotypes was found to correlate with a systematic and significant amplification of a mutant HRAS alÃ-ele.Tumors with high amplification levels of this oncogene were analyzed by chromosomal in situ hybridization; in four of the cases the amplified sequences did not reside at… (More)

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