Advances in Brief Substitutions That Compromise the Ionizing Radiation-induced Association of p 53 with 14-3-3 Proteins Also Compromise the Ability of p 53 to Induce Cell Cycle Arrest 1

@inproceedings{Stavridi2001AdvancesIB,
  title={Advances in Brief Substitutions That Compromise the Ionizing Radiation-induced Association of p 53 with 14-3-3 Proteins Also Compromise the Ability of p 53 to Induce Cell Cycle Arrest 1},
  author={Elena S. Stavridi and Nabil H. Chehab and Asra Malikzay and Thanos D Halazonetis},
  year={2001}
}
Ionizing radiation (IR) induces an increase in the levels and activity of the p53 tumor suppressor protein. The increased activity is attributed to IR-induced posttranslational modifications, some of which regulate the interaction of p53 with other proteins. One of these modifications is dephosphorylation of Ser, which leads to association of p53 with 14-3… CONTINUE READING