Advances in Brief Regulation of TCL 1 Expression in Band T-Cell Lymphomas and Reactive Lymphoid Tissues 1

Chromosomal rearrangements observed in T-cell prolymphocytic leukemia involve the translocation of one T-cell receptor gene to either chromosome 14q32 or Xq28, deregulating the expression of cellular protooncogenes of unknown function, such as TCL1 or its homologue,MTCP1. In the human hematopoietic system,TCL1 expression is predominantly observed in… CONTINUE READING