Advances in Brief Promoter Hypermethylation Patterns of p 16 , O 6-Methylguanine-DNA-methyltransferase , and Death-associated Protein Kinase in Tumors and Saliva of Head and Neck Cancer Patients 1

@inproceedings{Rosas2001AdvancesIB,
  title={Advances in Brief Promoter Hypermethylation Patterns of p 16 , O 6-Methylguanine-DNA-methyltransferase , and Death-associated Protein Kinase in Tumors and Saliva of Head and Neck Cancer Patients 1},
  author={Siane Lopes Bittencourt Rosas and Wayne M Koch and Maria da Gloria Carvalho and Li Wu and Joseph A. Califano and William H Westra and Jin Jen and David Sidransky},
  year={2001}
}
Aberrant promoter hypermethylation is common in head and neck cancer and may be useful as a marker for cancer cells. We examined whether cells with tumor-specific aberrant DNA-methylation might be found in the saliva of affected patients. We tested 30 patients with primary head and neck tumors using methylation-specific PCR searching for promoter hypermethylation of the tumor suppressor genep16(CDKN2A), the DNA repair gene O-methylguanine-DNA-methyltransferase(MGMT) and the putative metastasis… CONTINUE READING

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