Advances in Brief PTEN UpRegulates the Tumor Metastasis Suppressor Gene Drg-1 in Prostate and Breast Cancer

@inproceedings{Bandyopadhyay2004AdvancesIB,
  title={Advances in Brief PTEN UpRegulates the Tumor Metastasis Suppressor Gene Drg-1 in Prostate and Breast Cancer},
  author={Sucharita Bandyopadhyay and Sudha K. Pai and Shigeru Hirota and Sadahiro Hosobe and Taisei Tsukada and Kunio Miura and Yukio Takano and Ken Saito and Therese Commes and David Piquemal and Misako Watabe and Steven C. Gross and Ying Wang and Jodi I. Huggenvik and Kounosuke Watabe},
  year={2004}
}
PTEN (phosphatase and tensin homologue deleted on chromosome 10) has been shown to be inactivated in a wide variety of cancers, and the role of this gene as a tumor suppressor has been well established. On the other hand, results of recent animal studies as well as clinical evidence indicate that PTEN is also involved in tumor metastasis suppression. Although PTEN is known to play a key role in controlling cell growth and apoptosis, how PTEN exerts the metastasis suppressor function remains… CONTINUE READING