Advances in Brief Mutation of Kras Protooncogene Is Associated with Histological Subtypes in Human Mucinous Ovarian Tumors 1

Abstract

Materials and Methods A series of 57 mucinous and 47 serous ovarian tumors (adenomas, tumors of borderline malignancy, and carcinomas) were examined by polymerase chain reaction-single strand conformation polymorphism analysis and direct sequencing for mutations in codons 12, 13, and 61 of K-ras gene. Higher incidence of K-ras mutations was observed in… (More)

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