Advances in Brief Modulation of Hypoxia-inducible Factor 1 a Expression by the Epidermal Growth Factor / Phosphatidylinositol 3-Kinase / PTEN / AKT / FRAP Pathway in Human Prostate Cancer Cells : Implications for Tumor Angiogenesis and Therapeutics 1

@inproceedings{Zhong2000AdvancesIB,
  title={Advances in Brief Modulation of Hypoxia-inducible Factor 1 a Expression by the Epidermal Growth Factor / Phosphatidylinositol 3-Kinase / PTEN / AKT / FRAP Pathway in Human Prostate Cancer Cells : Implications for Tumor Angiogenesis and Therapeutics 1},
  author={Hua Zhong and Kelly A Chiles and David M. Feldser and Erik Laughner and Colleen F. Hanrahan and M J Georgescu and Jonathan W. Simons and Gregg L Semenza},
  year={2000}
}
Dysregulated signal transduction from receptor tyrosine kinases to phosphatidylinositol 3-kinase (PI3K), AKT (protein kinase B), and its effector FKBP-rapamycin-associated protein (FRAP) occurs via autocrine stimulation or inactivation of the tumor suppressor PTEN in many cancers. Here we demonstrate that in human prostate cancer cells, basal-, growth factor-, and mitogen-induced expression of hypoxia-inducible factor 1 (HIF-1) a, the regulated subunit of the transcription factor HIF-1, is… CONTINUE READING