Advances in Brief Loss of Wild-Type p 53 Bestows a Growth Advantage on Primary Cortical Astrocytes and Facilitates Their in Vitro Transformation 1

Abstract

Primary cortical astrocytes were belated from normal (+1+), heterozy gous (+1—), or homozygous(—/—)p53-knockout mice.The normal astro cytes grew slowly and underwent crisis after limited division, while the homozygously defective cells grew rapidly and without contact inhibition. These —I— cells could not initially form colonies in soft agarose… (More)

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