Advances in Brief In Vivo Monitoring of Capecitabine Metabolism in Human Liver by Fluorine Magnetic Resonance Spectroscopy at 1.5 and 3 Tesla Field Strength


In metastatic colorectal cancer the oral 5-fluorouracil (5FU) prodrug capecitabine is used with increasing frequency as an alternative to i.v. 5FU administration. The rate of conversion of capecitabine into 5 deoxy-5fluorouridine has been related to tumor response, and 5FU catabolites have been associated with 5FU-related systemic toxicity. Here we… (More)


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