Advances in Brief Immunochemical Detection of the Multidrug Resistance-associated Protein MRP in Human Multidrug-resistant Tumor Cells by Monoclonal Antibodies 1


We have generated rat and murine monoclonal antibodies against multidrug resistance-associated protein (MRP), a M,. 180,000-195,000 membrane glycoprotein involved in a non-P-glycoprotein multidrug re sistance of human tumor cells. The antibodies were raised against two different segments of MRP and found to be suitable for protein blot analyses… (More)

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