Advances in Brief Generation of Anti-p53 Cytotoxic T Lymphocytes from Human Peripheral Blood Using Autologous Dendritic Cells

Abstract

CTLs recognizing the HLA-A2.1-restricted, wild-type sequence p53 epitopes p53149–157 and p53264–272 were generated from CD8-enriched populations of nonadherent peripheral blood lymphocytes (PBLs) obtained from healthy donors. The PBLs were restimulated in vitro with peptidepulsed granulocyte macrophage colony-stimulating factorand interleukin (IL)-4-induced… (More)

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@inproceedings{Chikamatsu1999AdvancesIB, title={Advances in Brief Generation of Anti-p53 Cytotoxic T Lymphocytes from Human Peripheral Blood Using Autologous Dendritic Cells}, author={Kazuaki Chikamatsu and Koji Nakano and Walter J. Storkus and Ettore Appella and Michael T Lotze and T L Whiteside and Albert B. Deleo}, year={1999} }