Advances in Brief Frequent-Catenin Mutation and Cytoplasmic / Nuclear Accumulation in Pancreatic Solid-Pseudopapillary Neoplasm

@inproceedings{Tanaka2001AdvancesIB,
  title={Advances in Brief Frequent-Catenin Mutation and Cytoplasmic / Nuclear Accumulation in Pancreatic Solid-Pseudopapillary Neoplasm},
  author={Yukichi Tanaka and Keisuke Kato and Kenji Notohara and Hiroshi Hojo and Rieko Ijiri and Tetsumi Miyake and Noriyuki Nagahara and Fumiakai Sasaki and Norihiko Kitagawa and Yukio Nakatani and Yasutsugu Kobayashi},
  year={2001}
}
Significance of Wnt signaling with -catenin mutations on solid-pseudopapillary neoplasm (SPN) of the pancreas was studied by immunohistochemistry and molecular analysis. On immunohistochemistry, all 18 SPNs tested showed diffuse cytoplasmic/nuclear positivity for -catenin. Upon direct DNA sequencing of exon 3 of the -catenin gene, 15 (83%) of the 18 SPNs showed 1-bp missense mutation in codons 32 (5 cases), 33 (3 cases), 34 (3 cases), 37 (3 cases), and 41 (1 case). Immunoreactivity for cyclin… CONTINUE READING

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