Advances in Brief Correlation between E 2 F-1 Requirement in the S Phase and E 2 F-1 Transact ivation of Cell Cycle-related Genes in Human Cells 1

The mammalian nuclear protein E2F-1 has recently been cloned based on its ability to bind the retinoblastoma protein. To determine whether E2F-1 plays a role in the control of the cell proliferation, we introduced an inducible construct expressing an E2F-1 antisense RNA into the human glioblastoma T98G cell line and assessed DNA synthesis during the cell… (More)