Advances in Brief Combination Therapy Including a Gelatinase Inhibitor and Cytotoxic Agent Reduces Local Invasion and Metastasis of Murine Lewis Lung Carcinoma

@inproceedings{Anderson2006AdvancesIB,
  title={Advances in Brief Combination Therapy Including a Gelatinase Inhibitor and Cytotoxic Agent Reduces Local Invasion and Metastasis of Murine Lewis Lung Carcinoma},
  author={Ian C. Anderson and ' Margaret A. Shipp and Andrew J. P. Docherty and Beverly A Teicher},
  year={2006}
}
Theefficacyofcombinationtherapyincludinganoralgelatinaseinhib itor (CT1746)and cytotoxicagentwasanalyzedusingthe murineLewis lung carcinoma model. Primary tumors, pulmonary metastases, and sera from tumor-bearinganimalshadincreasedgelatinaseB activitythat was inhibited by CT1746levelsachievablein vivo.The combinationof CT1746 andcyclophosphamide (CTX) wassignificantlymoreeffectivethaneither singleagentin delayinglocal tumor growth(CT1746/CTX, 30.9 ±1.7 days;CT1746, 2.6 ±0.3 days;CTX, 19.5 ±1… CONTINUE READING

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