Advances in Brief Cleavage of-Catenin by Calpain in Prostate and Mammary Tumor Cells

Mutations in the NH2-terminal regulatory domain of the -catenin gene lead to aberrant stabilization and accumulation of the protein and increased TCF/LEF-dependent transcription. Although these mutations are common in some cancers, they are infrequent in prostate and breast cancer. We have found that metastatic prostate cancer specimens, obtained through a… (More)